| A Turn-On Fluorescence Sensing Platform for Rapid Determination of Tetracycline in Pharmaceutical Samples |
| کد مقاله : 1565-IWWA |
| نویسندگان |
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آزیتا ظاهری *1، رحمان حلاج2 1دانشجو دانشگاه کردستان 2عضو هیئت علمی دانشگاه کردستان |
| چکیده مقاله |
| Tetracycline is widely used in human and veterinary medicine, making its reliable determination important for pharmaceutical quality control and residue monitoring. Here, a turn-on fluorescence sensing platform was constructed by combining a newly prepared fluorescent carbon-based nanomaterial with manganese dioxide (MnO₂) nanosheets. The fluorescence emission of the nanomaterial near 493 nm was strongly quenched by MnO₂ and recovered after the addition of tetracycline. A stable response was read after 5 min. Fluorescence recovery increased with tetracycline concentration over the range of 0.32–72.45 µM. Under the tested conditions, tetracycline also produced a stronger response than the examined antibiotics and common matrix ions. The method was further evaluated using commercial tetracycline capsule and ointment samples by standard addition. Linear responses were obtained for both matrices(tetracycline ointment and, capsules) with R² values of 0.9847 and 0.9878, respectively. These findings support the use of the proposed platform for rapid determination of tetracycline in pharmaceutical samples. |
| کلیدواژه ها |
| Tetracycline, Fluorescent sensor, Antibiotic residues, Optical nanoprobe, Turn-on assay, Source monitoring |
| وضعیت: پذیرفته شده برای ارسال فایل های ارائه پوستر |
